Super P-Force (Sildenafil with Dapoxetine) – Patient Information for Australia
Basic Product Information
| INN (International Nonproprietary Name) | Sildenafil citrate & Dapoxetine hydrochloride |
| Common Brand Names in Australia | Super P-Force; other brands may include premixed sildenafil/dapoxetine generics, subject to TGA approval |
| ATC Code | G04BE03 (Sildenafil), N06AX21 (Dapoxetine) |
| Available Forms and Strengths | Tablets – 100 mg sildenafil and 60 mg dapoxetine per tablet |
| Manufacturers | Fortune Healthcare, Sunrise Remedies, and others (pending inclusion in the Australian Register of Therapeutic Goods, ARTG) |
| Prescription Status | Prescription-only medicine (Schedule 4 – S4); dispensed by Australian pharmacists with a valid script |
Mechanism of Action
- For Patients: Super P-Force combines two well-known medicines. Sildenafil treats erectile dysfunction (ED) by relaxing blood vessels in the penis, helping you get and keep an erection during sexual arousal. Dapoxetine treats premature ejaculation (PE) by slowing the nerves that make you ejaculate, helping you last longer during sex.
- For Specialists: Sildenafil is a selective PDE5 inhibitor, enhancing nitric oxide–dependent cyclic guanosine monophosphate (cGMP) accumulation in corpus cavernosum smooth muscle, resulting in vasodilation and improved erectile response to sexual stimulation. Dapoxetine is a short-acting selective serotonin reuptake inhibitor (SSRI), prolonging intravaginal ejaculatory latency through inhibitory serotonergic activity at central neural synapses.
Pharmacokinetics
- Absorption: Sildenafil and dapoxetine are both rapidly absorbed, with peak plasma levels in approximately 1–2 hours.
- Metabolism: Both drugs are largely metabolised by the liver (CYP3A4 and CYP2C19 for dapoxetine; CYP3A4 and CYP2C9 for sildenafil).
- Elimination: Excreted mainly via the kidneys as metabolites.
- Duration of Action: Sildenafil’s effects persist for up to 4–6 hours; dapoxetine shortens ejaculatory latency for approximately 1–3 hours post-dose.
Use in Everyday Life and Best Practices
Super P-Force is designed for adult men who want help with both erectile dysfunction (difficulty getting/keeping an erection) and premature ejaculation (coming too soon during sex). The standard dose is one tablet, taken about 1–3 hours before planned sexual activity. Do not take more than one tablet in 24 hours.
- Do not use if you do not have both ED and PE; for other cases, consult your GP or sexual health specialist.
- See your pharmacist or doctor if you’re unsure about the combined effects or drug interactions.
- Try to take the tablet with a glass of water and avoid high-fat meals immediately before dosing for best absorption.
Dosing in the Morning vs Evening
- Morning: Some men may prefer morning dosing for planned daytime intimacy; however, food can impact absorption and may be less predictable with daily routines.
- Evening: Most Australian patients favour evening dosing, aligning with typical sexual activity times and avoiding heavy meals close to intake. Evening use may also support better privacy and planning.
- Consistency: Take as needed, not daily. Regular timing (e.g., always before sex) helps you anticipate effects and manage side effects.
Taking with Food or on an Empty Stomach
- On an Empty Stomach: The effects of sildenafil are faster and stronger on an empty stomach. Try to leave 2–3 hours after a meal before taking your dose.
- With Food: Heavy or greasy English/Australian foods (e.g., pies, roasts, fish and chips) can delay absorption and reduce efficacy.
- Moderate meals (e.g., chicken salad, pasta, toast) have less effect but are still best separated from your dose.
- Tip: If you have dietary restrictions or diabetes, consult your GP or pharmacist for tailored advice.
Interaction Warnings
| Interaction Type | Specific Warning | Australian Context |
| Alcohol | Can increase risk of dizziness, fainting, low blood pressure | Avoid excess. Responsible alcohol use is key—consider alternatives if at risk. |
| Nitrates (e.g., GTN spray for angina) | Dangerous drop in blood pressure | Absolute contraindication; discuss alternatives with cardiologist. |
| Alpha-blockers (e.g., for prostate) | Can cause severe hypotension | Monitor blood pressure closely with your GP. |
| Antidepressants (SSRIs, MAOIs) | Risk of serotonin syndrome; additive side effects | Disclose all mental health treatments at pharmacy or doctor visits. |
| Antiretrovirals/Antifungals | Slows drug breakdown, raises side effect risk | Specialist management needed; common in HIV clinics. |
| Grapefruit juice | Increases blood levels of medicine | Limit grapefruit products. Extra caution with breakfast juices. |
| Other erectile dysfunction drugs (e.g., tadalafil, vardenafil) | Not to be used together | Risk of overdose and side effects. Use only one PDE5 inhibitor at a time. |
Indications
| Indication | Status in Australia | Use Notes |
| Treatment of co-occurring erectile dysfunction and premature ejaculation in adult men | Off-label (combination not currently TGA-licensed, but individual agents are) | Initiate under specialist or GP supervision |
| Monotherapy for isolated erectile dysfunction | No (use sildenafil-only products) | Super P-Force not recommended if you only have ED |
| Monotherapy for isolated premature ejaculation | No (use dapoxetine-only products) | Super P-Force not recommended if you only have PE |
Dosing According to Clinical Indications
| Patient Group | Recommended Dose | Notes/Adjustments |
| Healthy adults (18–64 years) | 1 tablet (100 mg sildenafil/60 mg dapoxetine) before sexual activity | Maximum once per 24 hours |
| Elderly (>65 years) | Not generally recommended | Use younger dose with extreme caution; lower doses/alternatives may be appropriate as assessed by a specialist |
| Renal/hepatic impairment | Avoid or use only with specialist supervision | Higher risk of side effects; dose adjustment required |
| Paediatric (<18 years) | Not suitable | Contraindicated for under-18s |
Safety Profile and Side Effects
- Common side effects (>1 in 10):
- Headache
- Flushing
- Dizziness or lightheadedness
- Indigestion, nausea
- Blocked or runny nose
- Sweating
- Uncommon/rare side effects:
- Blurred vision, changes in colour vision
- Ringing in ears (tinnitus)
- Palpitations, rapid heartbeat
- Changes in mood, anxiety, agitation
- Allergic reactions, including rash/swelling (seek urgent help)
- Fainting, severe drop in blood pressure
- Priapism (prolonged, painful erection lasting ≥4 hours — immediate emergency)
- Warnings:
Do not drive or operate machinery if you feel faint or lightheaded. Avoid use with nitrate medications. Contact your doctor or local pharmacist right away if you experience any severe or unexpected symptoms.
Guidelines for Proper Use (Advice from Australian Pharmacists/Clinics)
- Only take Super P-Force as prescribed by your GP or sexual health clinic.
- Always check the name and strength before each dose; use only medicine dispensed by a legitimate Australian pharmacy.
- Do not buy online without consulting your pharmacist about counterfeit risks.
- Keep out of reach of children.
- Store below 25°C, away from sunlight and moisture, consistent with Australian climate guidelines.
- If you miss a dose (for planned sex), simply take your next dose as needed. Do not double up tablets.
- Discuss any new symptoms or medicine changes with your GP or pharmacist promptly.
Alternative Treatment Options
- Sildenafil (Viagra®, Caverta®): Works for erections only; PBS-reimbursed for some indications. May be used alone if PE is not a concern.
- Dapoxetine (Priligy®): For premature ejaculation only; available with prescription, but not PBS-reimbursed as of 2024.
- Tadalafil (Cialis®): Longer-acting PDE5 inhibitor; may suit patients with frequent ED, but not PE; PBS status for selected patients.
- Psychological therapy (sex therapy, counselling): Particularly effective for psychological PE/ED or mixed causes; often recommended by Australian sexual health services.
- Other off-label SSRIs (paroxetine, sertraline): Sometimes prescribed for PE, but with more side effects and slower onset than dapoxetine.
Speak with your GP or sexual health specialist to determine the best approach and eligibility for subsidised (PBS) treatments as criteria may change.
Legal, Registration, and Reimbursement Status in Australia
- Regulation: Super P-Force in its combined form is not currently included on the Australian Register of Therapeutic Goods (ARTG) as of 2024; individual agents are available. Physicians may prescribe off-label under the Special Access Scheme (SAS).
- Prescription Requirements: Prescription-only (S4) — must be issued by an Australian-licensed doctor or specialist.
- Reimbursement: Sildenafil (ED indication) may be eligible for PBS subsidy in specific medical conditions; dapoxetine and combination therapy do not currently have PBS subsidy.
- Pharmacy Dispensing: Only reputable community or online pharmacies registered with the Pharmacy Board of Australia may dispense these medicines.
- Medicines Regulator: Therapeutic Goods Administration (TGA); prescription validity checked at time of dispensing.
Latest Research and Clinical Guidance (2022–2025)
- Combination therapy (sildenafil + dapoxetine) is supported by European, US, and select Asia-Pacific guidelines for men with both ED and PE who have failed single-agent therapy (European Urology 2023).
- Recent Australian studies highlight safe and effective use for select patients, especially where relationship and psychological factors are addressed in parallel (Sexual Health Journal, 2024).
- Adherence to best-practice standards, including exclusion of cardiovascular contraindications and assessment of psychological health, as per RACGP (Royal Australian College of General Practitioners) and ASHM (Australasian Society for HIV, Viral Hepatitis and Sexual Health Medicine) guidance (2024 update).
- Combined PDE5i/SSRI therapy should be considered only after assessing patient priorities and the impact on personal relationships (International Society for Sexual Medicine, 2025).
Availability and Delivery
- Popular pack sizes: 4, 8, and 12 tablets per pack.
- Indicative price: AUD $40–$80 per 4-tablet pack (price may vary by provider, script, and delivery location; not PBS eligible as of 2024).
| Major City | Estimated Pharmacy Delivery Times |
| Sydney | 1–2 business days (metro); up to 4 days (outer suburbs) |
| Melbourne | 1–2 business days (metro); 3–4 days (outer) |
| Brisbane | 1–3 business days |
| Perth | 2–4 business days |
| Adelaide | 1–3 business days |
| Regional Australia | 3–6 business days; check with pharmacy for rural/remote service coverage |
FAQ – Frequently Asked Questions
- 1. Can I take Super P-Force with alcohol?
Minimal alcohol may be tolerated, but larger amounts increase risk of side effects (dizziness, fainting, impaired sexual performance). It’s safest to limit alcohol when using this medication. - 2. Is it safe to buy Super P-Force online?
Only buy from legitimate Australian pharmacies with a prescription. Unregulated sources risk counterfeits, incorrect doses, and legal issues. - 3. How long does Super P-Force take to work?
Usually 1–2 hours after taking, on an empty stomach; effects last up to 4–6 hours for ED and 2–3 hours for PE. - 4. Can I use Super P-Force if I have heart problems?
If you have known heart disease, check with your cardiologist or GP first. It’s not suitable if you use nitrates or have unstable angina. - 5. What should I do if I get side effects?
Stop the medicine if you experience severe dizziness, vision changes, chest pain, or an erection lasting over 4 hours. Seek urgent medical attention if you have a serious reaction.
