Super Active Pack-40: Comprehensive Patient Guide
Basic Product Information
| International Nonproprietary Name (INN) | Super Active Pack-40 (contains Tadalafil 40 mg and Dapoxetine 60 mg) |
|---|---|
| Common Brand Names in Australia | Super Active Pack-40 (often generic; component names: Cialis, Priligy) |
| ATC Code | G04BE08 (Tadalafil), G04BE09 (Dapoxetine) |
| Available Forms & Strengths | Oral tablets; Tadalafil 40 mg + Dapoxetine 60 mg |
| Manufacturers | Varies by supplier (typically Indian generics manufacturers under Australian import licence) |
| Prescription Status | Prescription Only Medicine (Schedule 4) in Australia |
Super Active Pack-40 is a combination oral medication designed for men experiencing both erectile dysfunction (ED) and premature ejaculation (PE). Each tablet contains 40 mg of Tadalafil and 60 mg of Dapoxetine, helping support a satisfactory sexual experience. Both active ingredients are approved in Australia as individual therapies.
Mechanism of Action
- Tadalafil: A PDE5 inhibitor, Tadalafil relaxes the muscles of blood vessels in the penis, increasing blood flow upon sexual stimulation. This enables the ability to get and maintain an erection when sexually aroused.
- Dapoxetine: A selective serotonin reuptake inhibitor (SSRI) with a short half-life, Dapoxetine increases serotonin levels in the nervous system, helping to delay ejaculation by enhancing ejaculatory control.
For Specialists: Tadalafil acts by inhibiting phosphodiesterase type 5, resulting in increased cGMP levels in corpus cavernosum smooth muscle, promoting vasodilation. Dapoxetine selectively inhibits presynaptic serotonin reuptake, modulating spinal reflexes and central neurotransmission implicated in ejaculation latency.
Pharmacokinetics
- Absorption: Tadalafil achieves peak plasma concentrations within 2 hours of oral administration; Dapoxetine peaks in 1–2 hours.
- Metabolism: Tadalafil and Dapoxetine are metabolised primarily by the liver (CYP3A4 enzyme system).
- Elimination: Tadalafil’s half-life is approximately 17.5 hours; Dapoxetine’s is 1.5 hours. Tadalafil is excreted mainly in faeces (61%); Dapoxetine, via urine and faeces.
- Duration of Action: Tadalafil is effective for up to 36 hours (“weekend pill”), while Dapoxetine is short-acting (2–3 hours of effect).
Use in Everyday Life and Best Practices
Super Active Pack-40 is recommended for adult men who experience ED and PE simultaneously, and where separate therapies may be less convenient. In Australia, therapy should be individualised:
- Typical Dose: One tablet (Tadalafil 40 mg + Dapoxetine 60 mg) taken orally as needed, at least 30–60 minutes before anticipated sexual activity.
- Maximum Frequency: No more than once every 24 hours.
- Missed Dose: As a single-use medication, only take when needed; do not double up.
- Cautions: Do not use with other PDE5 inhibitors, nitrate medications, or MAO inhibitors.
- Avoid driving or operating heavy machinery if you feel dizzy, tired, or if you experience vision changes.
Discuss with your Australian GP, sexual health specialist, or pharmacist before use, especially if you have cardiovascular risk factors or chronic illnesses.
Dosing: Morning vs. Evening Use
- Morning: Allows for greater flexibility due to Tadalafil's long action (36 hours), but take care if driving or engaging in mentally demanding work until side effects are known.
- Evening: Preferred by most, reducing risk of daytime side effects. Take at least 30–60 minutes before sexual activity.
- Tips for Regularity: Use only as needed, not daily. Regular timing helps reduce forgetfulness and better predicts effect.
Always check how you react the first time before planning sexual activity.
Taking With Food or on an Empty Stomach
- With Food: Food, especially high-fat meals, may slow absorption of Tadalafil, delaying onset by up to 1 hour.
- On an Empty Stomach: Quicker onset and better absorption.
- Australian Dietary Habits: A light meal is preferable. Avoid heavy, greasy dinners before use.
Interaction Warnings
| Substance | Effect |
|---|---|
| Alcohol | Increases risk of dizziness, fainting, low blood pressure |
| Grapefruit juice | May raise blood levels of Tadalafil and Dapoxetine—avoid |
| Nitrate medications (e.g., angina medication) | Severe drop in blood pressure—contraindicated |
| Alpha-blockers (e.g., prazosin, tamsulosin) | May cause symptomatic hypotension—use caution |
| Other SSRIs, SNRIs | May increase risk of serotonin syndrome—avoid concurrent use |
| MAO inhibitors | Serious interactions—contraindicated |
| Strong CYP3A4 inhibitors (e.g., ketoconazole, ritonavir) | Increase serum levels—reduce dose or avoid |
| Herbal supplements (e.g., St John’s Wort) | May lower Dapoxetine levels—less effective |
Ask your pharmacist if you are unsure about drug or supplement interactions.
Indications
| Indication | Status |
|---|---|
| Erectile dysfunction (ED) with premature ejaculation (PE) in adult males | Approved |
| Erectile dysfunction alone | Not recommended (monotherapy preferred) |
| Premature ejaculation alone | Not recommended (monotherapy preferred) |
| Sexual dysfunction in women | Not indicated |
Dosing According to Clinical Indication
| Patient Group | Typical Dose | Notes |
|---|---|---|
| Adult males (18–64 years) | 1 tablet (Tadalafil 40 mg/Dapoxetine 60 mg), as needed | No more than once daily |
| Elderly (65+ years) | Use with caution; lower starting doses or alternative approaches may be safer | Greater sensitivity to side effects; consult specialist |
| Adolescents/Children | Not recommended | Safety and efficacy not established |
| Hepatic or severe renal impairment | Contraindicated | Risk of accumulation and toxicity |
Safety Profile / Side Effects
| Frequency | Side Effect |
|---|---|
| Common (>1/10) | Headache, flushing, nasal congestion, mild nausea, back pain, indigestion, dizziness, diarrhoea |
| Occasional (<1/10) | Blurred vision, tinnitus, dry mouth, anxiety, insomnia, excessive sweating |
| Rare (<1/1000) | Sudden hearing loss, chest pain, priapism (erection >4 hours), seizures, severe allergic reactions |
| Warnings | Do not use with cardiovascular disease, unstable angina, recent stroke or heart attack, severe hepatic or renal impairment |
- If you experience chest pain, vision or hearing loss, or an erection lasting longer than 4 hours, seek emergency medical help immediately.
- Report persistent or bothersome side effects to your GP or pharmacist.
Guidelines for Proper Use
- Always follow your doctor’s instructions regarding dose and timing.
- Do not share your medicine with others, even if their symptoms appear similar.
- Store in a cool, dry place out of reach of children.
- Do not use beyond expiry date printed on packaging.
- Review your other medications with your GP/pharmacist regularly to ensure no harmful interactions.
- Regular monitoring by an Australian prescriber is recommended, particularly for men with chronic health conditions.
- Maintain a healthy lifestyle including regular exercise, well-balanced diet, and limited alcohol consumption for maximised benefit.
Alternative Treatment Options (Available/Reimbursed in Australia)
- For erectile dysfunction:
- Sildenafil (Viagra, various generics): shorter acting, lower cost, available reimbursed for certain indications
- Vardenafil (Levitra)
- Avanafil (Spedra): rapid onset, some find milder side effects
- For premature ejaculation:
- Dapoxetine (Priligy): reimbursed under PBS for select cases; can be used alone
- Non-drug approaches: behavioural (stop–start, squeeze technique), psychological counseling (especially helpful for younger men)
- Pros & Cons:
- Combination therapy (as in Super Active Pack-40) offers convenience for dual diagnoses but increases the risk of side effects and interactions. Monotherapy may allow more precise dose and side effect control.
Legal, Registration, and Reimbursement Status in Australia
- Super Active Pack-40 as a fixed-dose combination is generally not available under the Pharmaceutical Benefits Scheme (PBS); component drugs may be partially reimbursed under certain criteria.
- Prescription required (Schedule 4) — must be prescribed by a registered Australian prescriber.
- Not available over-the-counter or via online international import without prescription—strictly regulated by the Therapeutic Goods Administration (TGA).
- Some online pharmacies may offer compounded versions under prescription; always ensure authenticity and legal compliance.
Latest Research / Clinical Guidance (2022–2025)
- Recent Australian Sexual Health Society and Urological Society guidelines recommend a personalised approach to sexual dysfunction, with combination therapy reserved for men who have not responded adequately to monotherapy.
- Meta-analyses (Smith & Anderson, BJU Int. 2023; Lee et al, J Sex Med. 2022) have demonstrated that combining a PDE5 inhibitor with Dapoxetine safely and effectively improves both erection quality and ejaculatory control, with satisfactory tolerability in most men.
- Ongoing research focuses on adjusting dose ratios for optimal balance of efficacy and side effects, especially among older men and those with comorbid depression or anxiety.
- No evidence supporting use in women or in men under 18 years of age.
Availability and Delivery
| Pack Size | No. of Tablets | Indicative Price |
|---|---|---|
| Small | 4 | $42–$58 |
| Medium | 12 | $110–$150 |
| Large | 24 | $200–$260 |
| City | Delivery Time (Business Days) |
|---|---|
| Sydney | 1–2 |
| Melbourne | 1–2 |
| Brisbane | 2–3 |
| Perth | 3–4 |
| Adelaide | 2–3 |
| Regional/Rural Areas | 3–5 |
Pharmacy home delivery requires photo ID and valid prescription at point of supply.
Frequently Asked Questions (FAQ)
- Can I buy Super Active Pack-40 without a prescription in Australia?
No. It is a prescription-only medication; selling or importing without a valid script is illegal under Australian law. - Can I drink alcohol while taking this medication?
Moderate alcohol increases your risk of dizziness and low blood pressure. Avoid or limit alcohol intake when using this product. - How quickly does Super Active Pack-40 work?
Onset is typically 30–60 minutes after taking the tablet, but can be delayed if taken with a heavy meal. - Can I take other medicines for depression together with this tablet?
No, combining with other SSRIs/SNRIs may cause serotonin syndrome. Consult your doctor before taking any other antidepressants. - What should I do if I get side effects?
Report mild side effects to your pharmacist or GP. If you experience severe reactions (e.g. chest pain, allergic reaction, prolonged erection), seek emergency help immediately.
For further advice, consult a registered Australian pharmacist or sexual health doctor. Always use medications as prescribed, and do not share your tablets with others.
