Super Avana (Avanafil with Dapoxetine) – Comprehensive Patient Information for Australia
Basic Product Information
| International Non-proprietary Names (INN) | Avanafil, Dapoxetine |
| Australia Brand Names | Super Avana (not an approved TGA-registered brand; available via certain online or compounding pharmacies) |
| Anatomical Therapeutic Chemical (ATC) Code | G04BE (Avanafil – Drugs used in erectile dysfunction), G04BE (Dapoxetine – Premature ejaculation) |
| Available Forms & Strengths | Tablets: Avanafil 100 mg + Dapoxetine 60 mg per tablet |
| Manufacturers | Sunrise Remedies Pvt Ltd and other generic pharmaceutical companies (offshore) |
| Prescription Status (AU) | Prescription Only Medicine (Schedule 4 under Poisons Standard); not available in standard Australian pharmacies, requires prescription/importation |
Mechanism of Action
- For Patients: Super Avana contains two active ingredients. Avanafil improves blood flow to the penis to help achieve and sustain an erection when sexually aroused; Dapoxetine increases levels of serotonin in the nervous system, which can help delay ejaculation and improve control during intercourse.
- For Specialists: Avanafil is a selective phosphodiesterase type 5 (PDE5) inhibitor, enhancing nitric oxide-mediated vasodilation in the corpus cavernosum. Dapoxetine is a short-acting selective serotonin reuptake inhibitor (SSRI) tailored for the treatment of premature ejaculation through inhibition of the serotonin transporter.
Pharmacokinetics (How the Body Handles Super Avana)
- Absorption: Both avanafil and dapoxetine are rapidly absorbed; avanafil reaches maximum blood levels in 30–45 minutes, while dapoxetine peaks in 1–2 hours.
- Metabolism: Metabolised mainly in the liver via CYP3A4 (avanafil) and CYP2D6/CYP3A4 (dapoxetine).
- Elimination: Primarily cleared in the faeces (avanafil) and urine (dapoxetine); average half-life: avanafil (5–10 hours), dapoxetine (1.3–1.6 hours).
- Duration of Action: Avanafil’s effect can last up to 6 hours; dapoxetine’s impact on ejaculation control lasts for 4–6 hours post-dose.
Use in Everyday Life and Best Practices
Super Avana is intended for adult men with both erectile dysfunction (ED) and premature ejaculation (PE). In Australia, it is not widely prescribed through the PBS but may be imported or compounded with a valid prescription. The recommended practical steps include:
- Usually, a single tablet (100 mg avanafil + 60 mg dapoxetine) is taken as needed about 30 to 60 minutes before sexual activity.
- Do not take more than one tablet in a 24-hour period.
- Only take the medication when sexual activity is anticipated.
- Consult your treating doctor to confirm suitability and dosage, especially when using new or compounded medications.
Dosing: Morning vs Evening
- Morning Dose: May be considered for individuals planning sexual activity earlier in the day; however, effects are typically needed just before activity, so daytime use is less common.
- Evening Dose: Most common; aligns with typical sexual activity patterns. Take 30–60 minutes prior to planned intercourse for optimal results.
- Tips: Try to use the medicine at similar times if you are very regular and avoid taking close to expected periods of sleep (to prevent insomnia).
Taking Super Avana with Food or on an Empty Stomach
- Super Avana can be taken with or without food.
- A high-fat meal can delay or slightly reduce the effectiveness of avanafil; for best results, consider taking on an empty stomach or after a light meal.
- Common Australian dietary habits, such as eating a big meal or drinking alcohol before intercourse, may reduce the onset and strength of the medication’s effects. Moderation is recommended.
Interaction Warnings
| Substance/Category | Interaction/Warning |
| Alcohol | May increase risk of dizziness, low blood pressure, fainting; limit to one or two standard drinks. |
| Grapefruit (juice/fruit) | Can affect drug levels in the body; avoid while using Super Avana. |
| Other PDE5 inhibitors (e.g., sildenafil, tadalafil, vardenafil) | Do not combine; may cause excessive low blood pressure or cardiac issues. |
| SSRIs, MAOIs, thioridazine | Risk of serotonin syndrome or cardiac arrhythmia; avoid concurrent use unless advised by a doctor. |
| Alpha-blockers, antihypertensives | May cause postural hypotension (sudden drops in blood pressure); monitor and inform your doctor. |
| Recreational drugs (nitrates, poppers, etc.) | Severe, potentially fatal drop in blood pressure; must NOT be used with any form of nitrate. |
Indications
| Indication | Status in AU |
| Treatment of erectile dysfunction (ED) and premature ejaculation (PE) in adult men | Off-label, not TGA registered as a combination product; individual components available separately by prescription |
| Other sexual performance disorders | Not officially indicated; off-label use only under prescriber supervision |
Dosing According to Clinical Indications
| Patient Group | Recommended Dose | Notes |
| Adults (18–64 years) | 1 tablet (100 mg avanafil/60 mg dapoxetine) as needed, 30–60 min prior to activity | Do not exceed 1 tablet in 24 hours |
| Elderly (65+ years) | Use with caution, generally start at the lowest dose or seek specialist advice | Possible increased side effects; monitor BP and cardiac status |
| Paediatric (<18 years) | Not indicated; use in children or adolescents is contraindicated | Seek specialist advice if unusual circumstances arise |
Safety Profile and Side Effects
- Common side effects:
- Headache, flushing, nasal congestion, dizziness
- Nausea, dry mouth, diarrhoea
- Insomnia, anxiety, mild vision changes
- Rare side effects:
- Severe low blood pressure, syncope (fainting)
- Palpitations, chest pain, arrhythmia
- Priapism (an erection lasting >4 hours; medical emergency)
- Seizures, serotonin syndrome (with other SSRIs or serotonergic drugs)
- Severe skin reactions, allergic symptoms (rash, swelling, difficulty breathing)
- Warnings and precautions: Always disclose all medications to your doctor or pharmacist before starting Super Avana. Consult a healthcare professional immediately if you experience chest pain, severe dizziness, prolonged erection or signs of an allergic reaction.
Guidelines for Proper Use
- Only take Super Avana if you have been prescribed the medicine for combined erectile dysfunction and premature ejaculation.
- Do not split the tablet; take whole with a full glass of water.
- Avoid excessive alcohol intake and recreational drugs.
- Let your doctor know if you have a heart, liver, or kidney condition, or if you are on any other medications.
- Store at room temperature, away from children and direct light.
- If a dose is missed, do not double up; just take as needed for sexual activity.
Alternative Treatment Options in Australia
- Sildenafil (Viagra): Widely available on prescription; reimbursed in some public schemes for specific ED conditions. Pros: Well-studied, familiar to doctors. Cons: Longer action in body, more food interactions.
- Tadalafil (Cialis): Long-acting, can be taken daily or as needed; available by prescription. Pros: Suitable for more spontaneity. Cons: Not always covered by public subsidy; possible muscle aches.
- Vardenafil (Levitra): Similar to sildenafil; available by prescription. Pros: Effective, different side-effect profile. Cons: Less popular; not subsidised.
- Dapoxetine standalone (Priligy): Short-acting SSRI approved for PE. Pros: Specifically registered for PE. Cons: Not always available on the PBS, requires prescription.
- Other non-drug therapies: Psychosexual counselling, pelvic floor training, lifestyle modification. These are recommended first-line for many individuals, particularly when psychosocial factors are present.
Legal, Registration, and Reimbursement Status in Australia
- Regulatory Bodies: Therapeutic Goods Administration (TGA) regulates medications in Australia.
- Super Avana Combination: Not TGA-registered as a combination medicine. Individual components may be prescribed by Australian physicians.
- Availability: Not supplied through standard pharmacies; may be available via compounding or special import through the TGA’s Special Access Scheme under prescription.
- Reimbursement: Not listed on the Pharmaceutical Benefits Scheme (PBS). Out-of-pocket costs should be expected.
Latest Research and Clinical Guidance (2022–2025)
- Recent English and international studies (Chung et al., 2023; European Urology Review, 2024) confirm the effectiveness and safety of avanafil for ED, and dapoxetine remains first-line for on-demand PE management. Combining PDE5 inhibitors with SSRIs is increasingly considered for men with both disorders when monotherapy fails, under specialist supervision.
- Australian and European guidelines recommend lifestyle modification, psychosexual therapy and medical management (as appropriate) as a combined approach. (EAU Guidelines, 2024; RACGP Update, 2023)
Availability and Delivery
| Pack Size | Indicative Price (AUD) | Estimated Delivery Time |
| 4 tablets | $60–$85 | 1–2 business days (Sydney, Melbourne, Brisbane) |
| 8 tablets | $110–$155 | 1–3 business days (all metro areas) |
| 12 tablets | $160–$220 | 2–5 business days (regional/remote WA, NT, TAS, QLD) |
Note: Prices and delivery times are indicative and may vary by supplier, shipping method, and region. Always confirm at point of sale.
Frequently Asked Questions (FAQ)
- Can I use Super Avana without a prescription in Australia?
No. Super Avana is a prescription-only medication. It is not registered for use in Australia but can be accessed through special importation or compounding with a valid doctor’s prescription. - Can I drink alcohol while taking Super Avana?
Limited alcohol use (1–2 standard drinks) is generally considered safe, but excessive drinking may increase side effects such as dizziness, low blood pressure, and fainting. - Is it safe to take Super Avana with other antidepressants?
No. Taking Super Avana, which contains dapoxetine (an SSRI), with other SSRIs, MAOIs, or serotonergic medications may increase the risk of serotonin syndrome or cardiac side effects. Always consult your doctor before combining medicines. - Can Super Avana be used by older men?
Super Avana may be used by older adults under medical supervision. Dose adjustments and careful monitoring for cardiovascular side effects are recommended, especially in men over 65. - Will my insurance or Medicare (PBS) cover Super Avana?
Super Avana is not listed on the PBS or generally covered by private insurance in Australia. All costs are out-of-pocket unless you access the drug via a specific clinical trial or other approved access pathway.
Conclusion
Super Avana combines two proven therapies for erectile dysfunction and premature ejaculation. While not officially registered in Australia, it may be prescribed or accessed under specialist supervision when individual therapies are insufficient. Consult your doctor or pharmacist for advice specific to your health, and report any side effects immediately.
